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DNA sequence variation in ACVR1C encoding the activin receptor-like kinase 7 influences body fat distribution and protects against type 2 diabetes

Abstract:

A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type 2 diabetes. We conducted an exome-wide association study of coding variation in UK Biobank (405,569 individuals) to identify variants that lower WHRadjBMI and protect against type 2 diabetes. We identified four variants in the gene ACVR1C (encoding the activin receptor-like kinase 7 receptor expressed on adipocytes and pancreatic β-cel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/db18-0857

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Role:
Author
ORCID:
0000-0002-2385-8259
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
68
Issue:
1
Pages:
226-234
Publication date:
2018-12-20
Acceptance date:
2018-10-21
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pmid:
30389748
Source identifiers:
939083
Language:
English
Pubs id:
pubs:939083
UUID:
uuid:05e2203d-942c-4ba7-9c16-43c2a68d6a84
Local pid:
pubs:939083
Deposit date:
2019-01-17

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