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Interferon alfa versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials: Chronic Myeloid Leukemia Trialists' Collaborative Group.

Abstract:

BACKGROUND: Several randomized clinical trials in chronic myeloid leukemia (CML) have reported better patient survival with interferon alfa (IFN alpha) than with standard chemotherapeutic agents, such as busulfan or hydroxyurea. However, the size and persistence of this survival benefit is uncertain. Our aim was to assess these reliably, both overall and in particular patient subgroups. METHODS: We collaborated in a worldwide overview of all clinical trials in which patients with CML were ran...

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Journal:
Journal of the National Cancer Institute
Volume:
89
Issue:
21
Pages:
1616-1620
Publication date:
1997-11-01
EISSN:
1460-2105
ISSN:
0027-8874
Source identifiers:
96029

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