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Journal article

The potential role for regulatory T-cell therapy in vascularized composite allograft transplantation.

Abstract:

PURPOSE OF REVIEW: Vascularized composite allograft (VCA) transplantation restores defects to a degree not possible by conventional techniques. However, it is limited by the need for long-term immunosuppression and high rates of acute rejection directed against skin. There is therefore a need for a therapy that may shift the risk-benefit ratio in favour of VCA transplantation. Regulatory T cells (Tregs) are a subset of T cells with potent immunoregulatory properties and the potential to promo...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Publisher:
Lippincott Williams and Wilkins
Journal:
Current opinion in organ transplantation
Volume:
19
Issue:
6
Pages:
558-565
Publication date:
2014-12-05
DOI:
EISSN:
1531-7013
ISSN:
1087-2418
URN:
uuid:05c81fa2-d322-4ff0-962e-177af0e8650c
Source identifiers:
488159
Local pid:
pubs:488159

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