Journal article
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes
- Abstract:
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Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme have previously been shown to induce a DNA damage response and, ultimately, cell death. High-throughput screens of human cancer cell-lines identify colorectal and gastric cell-lines with microsatellite instability (MSI) as enriched for cellular sensitivity to N-hydroxyurea series inhibitors of FEN1, but not the PARP ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 9.6MB)
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- Publisher copy:
- 10.1371/journal.pone.0179278
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Authors
Funding
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 12
- Issue:
- 6
- Pages:
- 0179278
- Publication date:
- 2017-06-19
- Acceptance date:
- 2017-05-27
- DOI:
- EISSN:
-
1932-6203
- Pmid:
-
28628639
- Source identifiers:
-
704564
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:704564
- UUID:
-
uuid:05c81cff-85e7-4261-af2d-05fb5c699d16
- Local pid:
- pubs:704564
- Deposit date:
- 2018-07-03
Terms of use
- Copyright holder:
- Ward et al
- Copyright date:
- 2017
- Notes:
-
© 2017 Ward et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
- Licence:
- CC Attribution (CC BY)
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