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Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes

Abstract:

Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme have previously been shown to induce a DNA damage response and, ultimately, cell death. High-throughput screens of human cancer cell-lines identify colorectal and gastric cell-lines with microsatellite instability (MSI) as enriched for cellular sensitivity to N-hydroxyurea series inhibitors of FEN1, but not the PARP ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0179278

Authors


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Role:
Author
ORCID:
0000-0003-0937-4554
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Oncology
Oxford college:
University College
Role:
Author
ORCID:
0000-0002-8679-4627
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Role:
Author
ORCID:
0000-0003-4209-7499
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
6
Pages:
0179278
Publication date:
2017-06-19
Acceptance date:
2017-05-27
DOI:
EISSN:
1932-6203
Pubs id:
pubs:704564
URN:
uri:05c81cff-85e7-4261-af2d-05fb5c699d16
UUID:
uuid:05c81cff-85e7-4261-af2d-05fb5c699d16
Local pid:
pubs:704564

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