Journal article icon

Journal article

Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids.

Abstract:

The consequences of improper regulation of collagen turnover include diseases such as tumor cell metastasis and arthritis. Several fluorogenic triple-helical peptide (fTHP) substrates have been constructed presently to examine collagenolytic behavior. These substrates incorporate L- or D-2-amino-3-(7-methoxy-4-coumaryl)propionic acid (Amp) or L- or D-2-amino-3-(6,7-dimethoxy-4-coumaryl)propionic acid (Adp) as the fluorophore and N-2,4-dinitrophenyl (Dnp) as the quencher. The desired sequences...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Expand authors...
Journal:
Analytical biochemistry
Volume:
321
Issue:
1
Pages:
105-115
Publication date:
2003-10-01
DOI:
EISSN:
1096-0309
ISSN:
0003-2697
Source identifiers:
226982
Language:
English
Keywords:
Pubs id:
pubs:226982
UUID:
uuid:05c4a6b7-c617-4d0c-9524-436aa545e4bd
Local pid:
pubs:226982
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP