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Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids.

Abstract:

The consequences of improper regulation of collagen turnover include diseases such as tumor cell metastasis and arthritis. Several fluorogenic triple-helical peptide (fTHP) substrates have been constructed presently to examine collagenolytic behavior. These substrates incorporate L- or D-2-amino-3-(7-methoxy-4-coumaryl)propionic acid (Amp) or L- or D-2-amino-3-(6,7-dimethoxy-4-coumaryl)propionic acid (Adp) as the fluorophore and N-2,4-dinitrophenyl (Dnp) as the quencher. The desired sequences...

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Publication status:
Published

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Authors


Lauer-Fields, JL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Leblanc, RM More by this author
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Journal:
Analytical biochemistry
Volume:
321
Issue:
1
Pages:
105-115
Publication date:
2003-10-05
DOI:
EISSN:
1096-0309
ISSN:
0003-2697
URN:
uuid:05c4a6b7-c617-4d0c-9524-436aa545e4bd
Source identifiers:
226982
Local pid:
pubs:226982

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