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HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

Abstract:

This study investigated the effects of 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (IOX3), a selective small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases, on mouse brains subject to transient focal cerebral ischaemia. Male, 8- to 12-week-old C57/B6 mice were subjected to 45 min of middle cerebral artery occlusion (MCAO) either immediately or 24 h after receiving IOX3. Mice receiving IOX3 at 20 mg/kg 24 h prior to the MCAO had better neuroscores and...

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Publication status:
Published

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Publisher copy:
10.1111/jnc.12804

Authors


Ogunshola, OO More by this author
Papadakis, M More by this author
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Journal:
Journal of neurochemistry
Volume:
131
Issue:
2
Pages:
177-189
Publication date:
2014-06-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:05b90fdd-b9e6-4c70-abd3-a569c7546be0
Source identifiers:
475740
Local pid:
pubs:475740
Language:
English
Keywords:

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