Journal article
HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
- Abstract:
-
This study investigated the effects of 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (IOX3), a selective small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases, on mouse brains subject to transient focal cerebral ischaemia. Male, 8- to 12-week-old C57/B6 mice were subjected to 45 min of middle cerebral artery occlusion (MCAO) either immediately or 24 h after receiving IOX3. Mice receiving IOX3 at 20 mg/kg 24 h prior to the MCAO had better neuroscores and...
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- Publication status:
- Published
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- Publisher copy:
- 10.1111/jnc.12804
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Bibliographic Details
- Journal:
- Journal of neurochemistry
- Volume:
- 131
- Issue:
- 2
- Pages:
- 177-189
- Publication date:
- 2014-06-05
- DOI:
- EISSN:
-
1471-4159
- ISSN:
-
0022-3042
- URN:
-
uuid:05b90fdd-b9e6-4c70-abd3-a569c7546be0
- Source identifiers:
-
475740
- Local pid:
- pubs:475740
Terms of use
- Copyright date:
- 2014
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