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A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth.

Abstract:

BACKGROUND: The stromal microenvironment and particularly the macrophage component of primary tumors influence their malignant potential. However, at the metastatic site the role of these cells and their mechanism of actions for establishment and growth of metastases remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Using animal models of breast cancer metastasis, we show that a population of host macrophages displaying a distinct phenotype is recruited to extravasating pulmonary metas...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0006562

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
PloS one More from this journal
Volume:
4
Issue:
8
Pages:
e6562
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:05b8c843-53d1-4b27-8753-beb825cb9511
Local pid:
pubs:131393
Source identifiers:
131393
Deposit date:
2012-12-19

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