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Rhodium-catalysed asymmetric allylic arylation of racemic halides with arylboronic acids.

Abstract:

Csp(2)-Csp(2) cross-coupling reactions between arylboronic acid and aryl halides are widely used in both academia and industry and are strategically important in the development of new agrochemicals and pharmaceuticals. Csp(2)-Csp(3) cross-coupling reactions have been developed, but enantioselective variations are rare and simply retaining the stereochemistry is a problem. Here we report a highly enantioselective Csp(2)-Csp(3) bond-forming method that couples arylboronic acids to racemic ally...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nchem.2360

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature chemistry Journal website
Volume:
7
Issue:
11
Pages:
935-939
Publication date:
2015-11-01
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
Language:
English
Pubs id:
pubs:575233
UUID:
uuid:05b74c99-1599-4515-aa4a-e243c0d8c635
Local pid:
pubs:575233
Source identifiers:
575233
Deposit date:
2015-11-29

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