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Targeting the fetal acetylcholine receptor in rhabdomyosarcoma.

Abstract:

INTRODUCTION: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence. Recent efforts to enhance overall survival of patients with clinically advanced RMS have failed and there is a demand for conceptually novel treatments. Immune therapeutic options targeting the fetal nicotinic acetylcholine receptor (fnAChR), which is broadly expressed on RMS, are novel approaches to overcome the therapeutic resistance of RMS. Expression of the fnAChR is restricted to de...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Expert opinion on therapeutic targets
Volume:
17
Issue:
2
Pages:
127-138
Publication date:
2013-02-05
DOI:
EISSN:
1744-7631
ISSN:
1472-8222
URN:
uuid:05b64136-fd70-41ee-be30-82e75b3d5669
Source identifiers:
379650
Local pid:
pubs:379650

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