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Amphipathic solvation of indole: implications for the role of tryptophan in membrane proteins.

Abstract:

The microscopic structure of the tryptophan side chain, indole, in an amphiphilic environment has been investigated using a combination of neutron diffraction measurements and simulations in solution. The results show that indole is preferentially solvated by hydrogen bonding interactions between water and alcohol -OH groups rather than the interaction being dominated by indole-methyl interactions. This has implications for understanding how tryptophan interacts with the amphipathic membrane ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jpcb.5b02476

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
American Chemical Society Publisher's website
Journal:
journal of physical chemistry. B Journal website
Volume:
119
Issue:
19
Pages:
5979-5987
Publication date:
2015-01-01
DOI:
EISSN:
1520-5207
ISSN:
1520-6106
Language:
English
Keywords:
Pubs id:
pubs:522998
UUID:
uuid:05b0886b-9443-4113-b667-cbf59f3c7580
Local pid:
pubs:522998
Source identifiers:
522998
Deposit date:
2015-11-27

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