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Reciprocal immunomodulation in a schistosome and hepatotropic virus coinfection model.

Abstract:

Human coinfection with the helminth parasite Schistosoma mansoni and hepatitis B and hepatitis C viruses is associated with increased hepatic viral burdens and severe liver pathology. In this study we developed a murine S. mansoni/lymphocytic choriomeningitis virus (LCMV) coinfection model that reproduces the enhanced viral replication and liver pathology observed in human coinfections, and used this model to explore the mechanisms involved. Viral coinfection during the Th2-dominated granulom...

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Publication status:
Published

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Journal:
Journal of Immunology More from this journal
Volume:
175
Issue:
10
Pages:
6275-6285
Publication date:
2005-11-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767

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