Journal article icon

Journal article

Ribosomal oxygenases are structurally conserved from prokaryotes to humans.

Abstract:

2-Oxoglutarate (2OG)-dependent oxygenases have important roles in the regulation of gene expression via demethylation of N-methylated chromatin components and in the hydroxylation of transcription factors and splicing factor proteins. Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA and ribosomal proteins have been shown to be important in translation relating to cellular growth, TH17-cell differentiation and translational accuracy. The finding that ribosomal oxy...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nature13263

Authors


Chowdhury, R More by this author
Sekirnik, R More by this author
Brissett, NC More by this author
Expand authors...
Journal:
Nature
Volume:
510
Issue:
7505
Pages:
422-426
Publication date:
2014-06-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:05a60f28-deb8-4c93-9d38-90686cf3df86
Source identifiers:
465009
Local pid:
pubs:465009

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP