Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.

Journal article

Asthma is caused by a combination of poorly understood genetic and environmental factors. We have systematically mapped the effects of single nucleotide polymorphisms (SNPs) on the presence of childhood onset asthma by genome-wide association. We characterized more than 317,000 SNPs in DNA from 994 patients with childhood onset asthma and 1,243 non-asthmatics, using family and case-referent panels. Here we show multiple markers on chromosome 17q21 to be strongly and reproducibly associated wi...

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Authors: Moffatt, M; Kabesch, M; Liang, L; Dixon, A; Strachan, D

• Publication status: Published
• Journal: Nature
• Volume: 448
• Issue: 7152
• Pages: 470-473
• Publication date: 2007-07-01
• DOI: 10.1038/nature06014
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Case-Control Studies; Humans; Membrane Proteins; RNA, Messenger; Gene Expression Regulation; Germany; Chromosomes, Human, Pair 17; Age of Onset; Asthma; Great Britain; Polymorphism, Single Nucleotide; Child; Genetic Predisposition to Disease