Lack of association of MYO9B genetic variants with coeliac disease in a British cohort.

Journal article

BACKGROUND AND AIMS: Development of coeliac disease involves an interaction between environmental factors (especially dietary wheat, rye, and barley antigens) and genetic factors (there is strong inherited disease susceptibility). The known human leucocyte antigen (HLA)-DQ2 and -DQ8 association explains only a minority of disease heritability. A recent study in the Dutch population suggested that genetic variation in the 3' region of myosin IXB (MYO9B) predisposes to coeliac disease. MYO9B is...

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Authors: Hunt, K; Monsuur, A; McArdle, W; Kumar, P; Travis, S

• Publication status: Published
• Journal: Gut
• Volume: 55
• Issue: 7
• Pages: 969-972
• Publication date: 2006-07-01
• DOI: 10.1136/gut.2005.086769
• EISSN: 1468-3288
• ISSN: 0017-5749
• Language: English
• Keywords: Case-Control Studies; Adolescent; Genetic Predisposition to Disease; Child, Preschool; Child; Gene Frequency; Humans; Great Britain; Aged, 80 and over; Adult; Female; Middle Aged; Celiac Disease; Polymorphism, Single Nucleotide; Aged; Myosins; Chi-Square Distribution; Male; Haplotypes