Journal article
DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans
- Abstract:
-
DNA-protein crosslinks (DPCs) are a specific type of DNA lesion consisting of a protein covalently and irreversibly bound to DNA, which arise after exposure to physical and chemical crosslinking agents. DPCs can be bulky and thereby pose a barrier to DNA replication and transcription. The persistence of DPCs during S phase causes DNA replication stress and genome instability. The toxicity of DPCs is exploited in cancer therapy: many common chemotherapeutics kill cancer cells by inducing DPC f...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- DNA Repair Journal website
- Volume:
- 71
- Pages:
- 198-204
- Publication date:
- 2018-08-23
- Acceptance date:
- 2018-08-23
- DOI:
- EISSN:
-
1568-7856
- ISSN:
-
1568-7864
- Pmid:
-
30170832
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:915437
- UUID:
-
uuid:059b76ef-e9fe-4bee-b25f-b4aa1226ce83
- Local pid:
- pubs:915437
- Source identifiers:
-
915437
- Deposit date:
- 2019-08-30
Terms of use
- Copyright date:
- 2018
- Notes:
-
Crown Copyright © 2018. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/BY/4.0/)
- Licence:
- CC Attribution (CC BY)
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