Short-term serotonergic but not noradrenergic antidepressant administration reduces attentional vigilance to threat in healthy volunteers.

Journal article

Anxiety is associated with threat-related biases in information processing such as heightened attentional vigilance to potential threat. Such biases are an important focus of psychological treatments for anxiety disorders. Selective serotonin reuptake inhibitors (SSRIs) are effective in the treatment of a range of anxiety disorders. The aim of this study was to assess the effect of an SSRI on the processing of threat in healthy volunteers. A selective noradrenergic reuptake inhibitor (SNRI), ...

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Authors: Murphy, SE; Yiend, J; Lester, K; Cowen, P; Harmer, C

• Publication status: Published
• Journal: international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)
• Volume: 12
• Issue: 2
• Pages: 169-179
• Publication date: 2009-03-01
• DOI: 10.1017/s1461145708009164
• EISSN: 1469-5111
• ISSN: 1461-1457
• Language: English
• Keywords: Anxiety; Decision Making; Double-Blind Method; Neuropsychological Tests; Attention; Female; Analysis of Variance; Adrenergic Uptake Inhibitors; Male; Serotonin Uptake Inhibitors; Time Factors; Citalopram; Morpholines; Young Adult; Humans; Adult; Reaction Time