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Journal article

Structural basis for RIFIN-mediated activation of LILRB1 in malaria

Abstract:

The Plasmodium species that cause malaria are obligate intracellular parasites, and disease symptoms occur as they replicate within human blood. Despite risking immune detection, the parasite delivers proteins that bind host receptors to infected erythrocyte surfaces. In the causative agent of the most deadly human malaria, Plasmodium falciparum, RIFINs form the largest erythrocyte surface protein family1. Some RIFINs can bind inhibitory immune r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41586-020-2530-3

Authors


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Role:
Author
ORCID:
0000-0003-1579-8484
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
Lincoln College
Role:
Author
ORCID:
0000-0002-1881-2424
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Role:
Author
ORCID:
0000-0001-5531-9244
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Role:
Author
ORCID:
0000-0002-5926-7768
Publisher:
Nature Research
Journal:
Nature More from this journal
Volume:
587
Pages:
309-312
Place of publication:
England
Publication date:
2020-07-10
Acceptance date:
2020-07-06
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
32650338
Language:
English
Keywords:
Pubs id:
1119010
Local pid:
pubs:1119010
Deposit date:
2020-07-17

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