Journal article
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity.
- Abstract:
-
We report the development of a new group of nonnucleoside reverse transcriptase inhibitors (NNRTIs). One of the most active congeners of this series of 1,1,3-trioxo-2H,4H-thieno[3,4-e] [1,2,4]thiadiazine (TTD) derivatives, i.e., 2-(3-fluorobenzyl)-4-cyanomethylen-l,1,3-trioxo-2H,4H- thieno [3,4-e] [1,2,4] thiadiazine) (QM96639) was found to inhibit human immunodeficiency virus (HIV) type 1 [HIV-1 (IIIB)] replication in MT-4 cells at a concentration of 0.09 microM. This compound was toxic for ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 42
- Issue:
- 3
- Pages:
- 618-623
- Publication date:
- 1998-03-01
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- Source identifiers:
-
5995
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:5995
- UUID:
-
uuid:058af157-69b8-4b17-9f52-04501bad9a1b
- Local pid:
- pubs:5995
- Deposit date:
- 2012-12-19
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- Copyright date:
- 1998
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