1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity.

Witvrouw, M; Arranz, ME; Pannecouque, C; Declercq, R; Jonckheere, H; Schmit, JC; Vandamme, AM; Diaz, JA; Ingate, ST; Desmyter, J; Esnouf, R; Van Meervelt, L; Vega, S; Balzarini, J; De Clercq, E

Abstract:

We report the development of a new group of nonnucleoside reverse transcriptase inhibitors (NNRTIs). One of the most active congeners of this series of 1,1,3-trioxo-2H,4H-thieno[3,4-e] [1,2,4]thiadiazine (TTD) derivatives, i.e., 2-(3-fluorobenzyl)-4-cyanomethylen-l,1,3-trioxo-2H,4H- thieno [3,4-e] [1,2,4] thiadiazine) (QM96639) was found to inhibit human immunodeficiency virus (HIV) type 1 [HIV-1 (IIIB)] replication in MT-4 cells at a concentration of 0.09 microM. This compound was toxic for ...

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APA Style

Witvrouw, M., Arranz, M. E., Pannecouque, C., Declercq, R., Jonckheere, H., Schmit, J. C., Vandamme, A. M., Diaz, J. A., Ingate, S. T., Desmyter, J., Esnouf, R., Van Meervelt, L., Vega, S., Balzarini, J., & De Clercq, E. (1998). 1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity. Antimicrobial Agents and Chemotherapy, 42(3), 618–623.

MLA Style

Witvrouw, M., et al. “1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity.” Antimicrobial Agents and Chemotherapy, vol. 42, no. 3, 1998, pp. 618–23.

Chicago Style

Witvrouw, M, ME Arranz, C Pannecouque, R Declercq, H Jonckheere, JC Schmit, AM Vandamme, et al. 1998. “1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity.” Antimicrobial Agents and Chemotherapy 42 (3): 618–23.
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