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1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity.

Abstract:

We report the development of a new group of nonnucleoside reverse transcriptase inhibitors (NNRTIs). One of the most active congeners of this series of 1,1,3-trioxo-2H,4H-thieno[3,4-e] [1,2,4]thiadiazine (TTD) derivatives, i.e., 2-(3-fluorobenzyl)-4-cyanomethylen-l,1,3-trioxo-2H,4H- thieno [3,4-e] [1,2,4] thiadiazine) (QM96639) was found to inhibit human immunodeficiency virus (HIV) type 1 [HIV-1 (IIIB)] replication in MT-4 cells at a concentration of 0.09 microM. This compound was toxic for ...

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Publication status:
Published

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Journal:
Antimicrobial agents and chemotherapy
Volume:
42
Issue:
3
Pages:
618-623
Publication date:
1998-03-05
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:058af157-69b8-4b17-9f52-04501bad9a1b
Source identifiers:
5995
Local pid:
pubs:5995

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