Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection.

Journal article

ABSTRACT: A large quantitative study was carried out to compare the proteome of respiratory syncytial virus (RSV) infected versus uninfected cells in order to determine novel pathways regulated during viral infection. RSV infected and mock-infected HEp2 cells were lysed and proteins separated by preparative isoelectric focussing using offgel fractionation. Following tryptic digestion, purified peptides were characterized using label-free quantitative expression profiling by nano-ultra perform...

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Authors: Ternette, N; Wright, C; Kramer, H; Altun, M; Kessler, B

• Publication status: Published
• Journal: Virology journal
• Volume: 8
• Issue: 1
• Pages: 442
• Publication date: 2011-01-01
• DOI: 10.1186/1743-422x-8-442
• EISSN: 1743-422X
• ISSN: 1743-422X
• Language: English
• Keywords: XRN2; mass spectrometry; IFIT3; label-free quantitative proteomics; Respiratory syncytial virus