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The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection.

Abstract:

Hepatitis C virus (HCV) readily sets up a persistent infection and is a major cause of liver disease worldwide. Interferon alfa and ribavirin therapy lead to sustained clearance of virus in 31% to 64% of patients with type 1 and non-type 1 genotypes, respectively. It is not clear to what extent these drugs act directly to reduce HCV replication, or indirectly via host immune responses, and what evoked immune responses are associated with clinical outcome. We have examined prospectively 15 pat...

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Publication status:
Published

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Publisher copy:
10.1053/jhep.2002.35344

Authors


Journal:
Hepatology (Baltimore, Md.) More from this journal
Volume:
36
Issue:
3
Pages:
743-754
Publication date:
2002-09-01
DOI:
EISSN:
1527-3350
ISSN:
0270-9139

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