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Transcription termination and RNA degradation contribute to silencing of RNA polymerase II transcription within heterochromatin.

Abstract:

Within the heterochromatin of budding yeast, RNA polymerase II (RNAPII) transcription is repressed by the Sir2 deacetylase. Although heterochromatic silencing is generally thought to be due to limited accessibility of the underlying DNA, there are several reports of RNAPII and basal transcription factors within silenced regions. Analysis of the rDNA array revealed cryptic RNAPII transcription within the "nontranscribed" spacer region. These transcripts are terminated by the Nrd1/Sen1 complex ...

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Publication status:
Published

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Journal:
Molecular cell More from this journal
Volume:
29
Issue:
3
Pages:
313-323
Publication date:
2008-02-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Language:
English
Keywords:
Pubs id:
pubs:100533
UUID:
uuid:057ab933-93eb-4005-a6ec-139a7b824ebb
Local pid:
pubs:100533
Source identifiers:
100533
Deposit date:
2012-12-19

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