Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.

Journal article

We develop a model of tyrosine phosphorylation and activation of the T-cell receptor (TCR) by localization to regions of close membrane-membrane proximity (close contact) that physically exclude tyrosine phosphatases such as CD45. Phosphatase exclusion generates regions of low phosphatase and high kinase activity and thus our model provides a framework to examine the kinetic segregation model of TCR activation. We incorporate a sequence of activation steps modeling the construction of the sig...

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Authors: Burroughs, N; Lazic, Z; Van Der Merwe, P

• Publication status: Published
• Journal: Biophysical journal
• Volume: 91
• Issue: 5
• Pages: 1619-1629
• Publication date: 2006-09-01
• DOI: 10.1529/biophysj.105.080044
• EISSN: 1542-0086
• ISSN: 0006-3495
• Language: English
• Keywords: Humans; Protein Tyrosine Phosphatases; Antigens; Cytokines; Ligands; Lymphocyte Activation; Models, Immunological; Phosphotransferases; Receptors, Antigen, T-Cell; Immunologic Factors; T-Lymphocytes; Signal Transduction; Animals