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Journal article

In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis.

Abstract:

OBJECTIVE:

To develop enzyme-activatable Förster resonance energy transfer (FRET) substrate probes to detect matrix metalloproteinase 12 (MMP-12) and MMP-13 activities in vivo in mouse models of inflammatory arthritis.

METHODS:

Peptidic FRET probes activated by MMP-12 and MMP-13 were reverse designed from inhibitors selected from a phosphinic peptide inhibitor library. Selectivity of the probes was demonstrated in vitro using MMP-1, MMP-2, MMP-3, MMP-12, and MMP-13...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/art.38295

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Arthritis Research UK More from this funder
European Union More from this funder
Publisher:
Wiley Publisher's website
Journal:
Arthritis and rheumatology (Hoboken, N.J.) Journal website
Volume:
66
Issue:
3
Pages:
589-598
Publication date:
2014-03-01
DOI:
EISSN:
2326-5205
ISSN:
2326-5191
Source identifiers:
451086
Language:
English
Keywords:
Pubs id:
pubs:451086
UUID:
uuid:0569d810-8713-4f8b-84ab-383548b21022
Local pid:
pubs:451086
Deposit date:
2014-09-14

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