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Journal article

In vivo enhancer analysis of human conserved non-coding sequences.

Abstract:

Identifying the sequences that direct the spatial and temporal expression of genes and defining their function in vivo remains a significant challenge in the annotation of vertebrate genomes. One major obstacle is the lack of experimentally validated training sets. In this study, we made use of extreme evolutionary sequence conservation as a filter to identify putative gene regulatory elements, and characterized the in vivo enhancer activity of a large group of non-coding elements in the huma...

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Publication status:
Published

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Publisher copy:
10.1038/nature05295

Authors


Pennacchio, LA More by this author
Prabhakar, S More by this author
Nobrega, MA More by this author
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Journal:
Nature
Volume:
444
Issue:
7118
Pages:
499-502
Publication date:
2006-11-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:056410ae-6020-4c31-b207-ebd2a39a6703
Source identifiers:
68001
Local pid:
pubs:68001

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