Tethered Aminohydroxylation Reaction and Its Application to Total Synthesis

Journal article

This review highlights key aspects of the Tethered Aminohydroxylation from its discovery to its current incarnation, which employs N,O-acylated derivatives as reoxidants for osmium. The potential and generality of this reaction has been demonstrated by its application in the synthesis of several natural products. A review of the recently developed N-O reoxidants for the tethered aminohydroxylation (TA) reaction is presented. All aspects of the aminohydroxylation reactions that are facilitated are discussed, together with their application in total synthesis. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.

Authors: Donohoe, T; Callens, C; Lacy, A; Winter, C

• Publication status: Published
• Journal: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
• Volume: 2012
• Issue: 4
• Pages: 655-663
• Publication date: 2012-02-01
• DOI: 10.1002/ejoc.201101464
• EISSN: 1099-0690
• ISSN: 1434-193X
• Language: English
• Keywords: Amines; Osmium; Total synthesis; Synthetic meth-ods; Amino alcohols