Journal article
Diastereoselective conjugate reduction with samarium diiodide: asymmetric synthesis of methyl (2S,3R)-N-acetyl-2-amino-2,3-dideuterio-3-phenylpropionate.
- Abstract:
- A highly diastereoselective conjugate reduction using SmI2 and D2O has been demonstrated on a homochiral benzylidene diketopiperazine template, giving methyl (2S,3R)-N-acetyl-2-amino-2,3-dideuterio-3-phenylpropionate in 93% de and 90% ee after deprotection, hydrolysis and N-acetylation.
- Publication status:
- Published
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- Publisher copy:
- 10.1039/b408257e
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Authors
Bibliographic Details
- Journal:
- Chemical communications (Cambridge, England)
- Volume:
- 10
- Issue:
- 21
- Pages:
- 2502-2503
- Publication date:
- 2004-11-05
- DOI:
- EISSN:
-
1364-548X
- ISSN:
-
1359-7345
- URN:
-
uuid:05605471-12ef-4669-b20c-57714d02c787
- Source identifiers:
-
110545
- Local pid:
- pubs:110545
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2004
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