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Immunosuppression with monoclonal antibodies. A model to determine the rules for effective serotherapy.

Abstract:

Despite the range of available T cell specific monoclonal antibodies, there are no established rules to predict which might be immunosuppressive. We here describe a series of five rat monoclonal antibodies to a defined T cell antigen (mouse Thy-1) and evaluate their ability to immunosuppress mice. When compared with rabbit anti-lymphocyte globulin, only one of these monoclonal antibodies was able to delay skin allograft rejection and eliminate antibody responses to sheep red blood cells. This...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Molecular biology and medicine More from this journal
Volume:
1
Issue:
3
Pages:
285-304
Publication date:
1983-10-01
ISSN:
0735-1313
Language:
English
Keywords:
Pubs id:
pubs:11447
UUID:
uuid:055f8abb-dd05-458d-8d6c-21742c43c1ca
Local pid:
pubs:11447
Source identifiers:
11447
Deposit date:
2013-02-20

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