Severe cytopenias associated with the sequential use of busulphan and interferon-alpha in chronic myeloid leukaemia.

Journal article

We describe four patients who developed severe thrombocytopenia which progressed to aplasia after the use of alpha-interferon in maintenance therapy of chronic phase CML after busulphan induction. On reviewing over 400 patients in the MRC CML III trial we found that there is a risk of cytopenia developing after busulphan therapy and a lesser risk of cytopenias developing after alpha-interferon therapy. If the therapies are given in a sequential fashion the risk of cytopenia developing appears...

Expand abstract

Authors: Shepherd, P; Richards, S; Allan, N

• Publication status: Published
• Journal: British journal of haematology
• Volume: 86
• Issue: 1
• Pages: 92-96
• Publication date: 1994-01-01
• DOI: 10.1111/j.1365-2141.1994.tb03257.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Thrombocytopenia; Middle Aged; Adult; Bone Marrow Diseases; Combined Modality Therapy; Humans; Hydroxyurea; Busulfan; Aged; Interferon-alpha; Female; Male; Leukemia, Myelogenous, Chronic, BCR-ABL Positive