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The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability.

Abstract:

The relationship of relapses to long-term disability in multiple sclerosis is uncertain. Relapse reduction is a common therapeutic target but clinical trials have shown dissociation between relapse suppression and disability accumulation. We investigated relationships between relapses and disability progression for outcomes of requiring assistance to walk, being bedridden and dying from multiple sclerosis [Disability Status Scale 6, 8, 10] by analysing 28 000 patient-years of evolution in 806...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awq118

Authors


Scalfari, A More by this author
Neuhaus, A More by this author
Degenhardt, A More by this author
Muraro, PA More by this author
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Journal:
Brain : a journal of neurology
Volume:
133
Issue:
Pt 7
Pages:
1914-1929
Publication date:
2010-07-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:0559ead5-7990-4b36-b923-462f90f72f9f
Source identifiers:
60452
Local pid:
pubs:60452

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