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Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.

Abstract:

Arylamine N-acetyltansferase (NAT) from Mycobacterium tuberculosis (TBNAT) is a potential drug target for anti-tubercular therapy. Recombinant TBNAT is much less soluble and is produced in lower yields than the closely related NAT from Mycobacterium marinum (MMNAT). In order to explore MMNAT as a model for TBNAT in drug discovery, we compare the two mycobacterial NAT enzymes. Two site-directed mutants of MMNAT have been prepared and characterised: MMNAT71, Tyr --> Phe and MMNAT209, Met --&...

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Publication status:
Published

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Publisher copy:
10.1007/s10930-009-9193-0

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry, BHF Centre of Research Excellence
Role:
Author
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Journal:
The protein journal
Volume:
28
Issue:
6
Pages:
281-293
Publication date:
2009-08-05
DOI:
EISSN:
1875-8355
ISSN:
1572-3887
URN:
uuid:055479fd-be71-4ee8-a121-0bddded2ce81
Source identifiers:
264067
Local pid:
pubs:264067

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