Journal article
Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.
- Abstract:
-
Arylamine N-acetyltansferase (NAT) from Mycobacterium tuberculosis (TBNAT) is a potential drug target for anti-tubercular therapy. Recombinant TBNAT is much less soluble and is produced in lower yields than the closely related NAT from Mycobacterium marinum (MMNAT). In order to explore MMNAT as a model for TBNAT in drug discovery, we compare the two mycobacterial NAT enzymes. Two site-directed mutants of MMNAT have been prepared and characterised: MMNAT71, Tyr --> Phe and MMNAT209, Met --&...
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- Publication status:
- Published
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- Publisher copy:
- 10.1007/s10930-009-9193-0
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Authors
Bibliographic Details
- Journal:
- The protein journal
- Volume:
- 28
- Issue:
- 6
- Pages:
- 281-293
- Publication date:
- 2009-08-05
- DOI:
- EISSN:
-
1875-8355
- ISSN:
-
1572-3887
- URN:
-
uuid:055479fd-be71-4ee8-a121-0bddded2ce81
- Source identifiers:
-
264067
- Local pid:
- pubs:264067
Item Description
Terms of use
- Copyright date:
- 2009
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