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Gene-environment interaction impacts on heart development and embryo survival

Abstract:

Congenital heart disease (CHD) is the most common type of birth defect. In recent years, research has focussed on identifying the genetic causes of CHD. However, only a minority of CHD cases can be attributed to single gene mutations. In addition, studies have identified different environmental stressors that promote CHD, but the additive effect of genetic susceptibility and environmental factors is poorly understood. In this context, we have investigated the effects of short-term gestational...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.172957

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Publisher:
Company of Biologists Publisher's website
Journal:
Development Journal website
Volume:
146
Issue:
2019
Article number:
dev172957
Publication date:
2019-02-20
Acceptance date:
2019-01-22
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Source identifiers:
976087
Language:
English
Keywords:
Pubs id:
pubs:976087
UUID:
uuid:054e44d4-45ae-4f8c-aa28-f37c697cccb8
Local pid:
pubs:976087
Deposit date:
2019-02-25

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