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Vulnerability to Alzheimer's pathology in neocortex: The roles of plasticity and columnar organization

Abstract:

Two principal findings in the Pearson et al. paper [73] are commented on here. The first is the regional selectivity within the cerebrum of neurofibrillary tangle (NFT) formation in Alzheimer's disease (AD) which targets association cortex and the primary olfactory cortex alone among regions of primary sensory cortex. The second finding is the clustering of NFT in columns of supra- and infra-granular layers of association cortex. We review recent evidence confirming these findings and comment...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
JOURNAL OF ALZHEIMERS DISEASE More from this journal
Volume:
9
Issue:
SUPPL. 3
Pages:
79-89
Publication date:
2006-01-01
ISSN:
1387-2877
Language:
English
Keywords:
Pubs id:
pubs:242986
UUID:
uuid:054d5b55-f9f7-4a0a-9f3c-5729854199a9
Local pid:
pubs:242986
Source identifiers:
242986
Deposit date:
2012-12-19

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