Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion.

Journal article

Natural killer (NK) cells are activated early during inflammatory events and contribute to the shaping of the ensuing adaptive immune response. To further understand the role for NK cells in inflammation, we investigated the phenotype and function of synovial fluid (SF) NK cells from patients with chronic joint inflammation, as well as from patients with transient inflammation of the knee following trauma. We confirm that synovial NK cells are similar to the well-characterized CD56(bright) pe...

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Authors: de Matos, C; Berg, L; Michaëlsson, J; Felländer-Tsai, L; Kärre, K

• Publication status: Published
• Journal: Immunology
• Volume: 122
• Issue: 2
• Pages: 291-301
• Publication date: 2007-10-01
• DOI: 10.1111/j.1365-2567.2007.02638.x
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: NK Cell Lectin-Like Receptor Subfamily D; Cells, Cultured; Coculture Techniques; Humans; Knee Joint; Immunophenotyping; Adult; Middle Aged; Osteoarthritis, Knee; Receptors, Natural Killer Cell; Killer Cells, Natural; Cytokines; NK Cell Lectin-Like Receptor Subfamily C; HLA Antigens; Histocompatibility Antigens Class I; Synovial Fluid; Aged; Knee Injuries; Receptors, Immunologic