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Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.

Abstract:

Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been clea...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.4269/ajtmh.14-0031

Authors


Venkatesan, M More by this author
Gadalla, NB More by this author
Stepniewska, K More by this author
Nsanzabana, C More by this author
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Publisher:
American Society of Tropical Medicine and Hygiene
Journal:
The American Journal of Tropical Medicine and Hygiene
Volume:
91
Issue:
4
Pages:
833-843
Publication date:
2014-07-21
Acceptance date:
2014-04-22
DOI:
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:0546a371-d2d6-42a0-a543-b583776c65d0
Source identifiers:
477447
Local pid:
pubs:477447
Language:
English
Keywords:

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