- Abstract:
-
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been clea...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 436.1kb)
-
(pdf, 25.6kb)
-
(pdf, 434.5kb)
-
- Publisher copy:
- 10.4269/ajtmh.14-0031
-
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- Publisher:
- American Society of Tropical Medicine and Hygiene
- Journal:
- The American Journal of Tropical Medicine and Hygiene
- Volume:
- 91
- Issue:
- 4
- Pages:
- 833-843
- Publication date:
- 2014-07-21
- Acceptance date:
- 2014-04-22
- DOI:
- EISSN:
-
1476-1645
- ISSN:
-
0002-9637
- URN:
-
uuid:0546a371-d2d6-42a0-a543-b583776c65d0
- Source identifiers:
-
477447
- Local pid:
- pubs:477447
- Language:
- English
- Keywords:
- Copyright holder:
- The American Society of Tropical Medicine and Hygiene
- Copyright date:
- 2014
- Notes:
- Copyright © 2014 by The American Society of Tropical Medicine and Hygiene. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.
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