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Blood flow redistribution and ventilation-perfusion mismatch during embolic pulmonary arterial occlusion.

Abstract:

Acute pulmonary embolism causes redistribution of blood in the lung, which impairs ventilation/perfusion matching and gas exchange and can elevate pulmonary arterial pressure (PAP) by increasing pulmonary vascular resistance (PVR). An anatomically-based multi-scale model of the human pulmonary circulation was used to simulate pre- and post-occlusion flow, to study blood flow redistribution in the presence of an embolus, and to evaluate whether reduction in perfused vascular bed is sufficient ...

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Publisher copy:
10.4103/2045-8932.87302

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Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Role:
Author
Journal:
Pulmonary circulation
Volume:
1
Issue:
3
Pages:
365-376
Publication date:
2011-01-01
DOI:
EISSN:
2045-8940
ISSN:
2045-8932
URN:
uuid:05464697-b759-45e8-94fa-4875aa71b7e8
Source identifiers:
259305
Local pid:
pubs:259305

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