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Tracking virus-specific CD4+ T cells during and after acute hepatitis C virus infection.

Abstract:

BACKGROUND: CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving chronic hepatitis C CD4+ T cell helper responses appear to be absent or short-lived, using functional assays. METHODOLOGY/PRINCIPAL FINDINGS: Here we used a novel HLA-DR1 tetramer containing a highly targeted CD4+ T cell epitope from the hepatitis C virus non-structural protein 4 to track number and phenotype ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0000649

Authors


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Institution:
University of Oxford
Role:
Author
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Name:
VIRGIL European Network of Excellence on Antiviral Drug Resistance
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Name:
Kompetenznetz Hepatitis HepNet
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Name:
James Martin School of the 21st Century, Oxford
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Volume:
2
Issue:
7
Article number:
e649
Publication date:
2007-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203

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