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Journal article

Iron, oxygen, and the pulmonary circulation.

Abstract:

The human pulmonary vasculature vasoconstricts in response to a reduction in alveolar oxygen tension, a phenomenon termed hypoxic pulmonary vasoconstriction (HPV). This review describes the time course of this behavior, which occurs in distinct phases, and then explores the importance for HPV of the hypoxia-inducible factor (HIF) pathway. Next, the HIF-hydroxylase enzymes that act as molecular oxygen sensors within the HIF pathway are discussed. These enzymes are particularly sensitive to int...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1152/japplphysiol.00179.2015

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
National Institute for Health Research More from this funder
Publisher:
American Physiological Society Publisher's website
Journal:
Journal of Applied Physiology Journal website
Volume:
119
Issue:
12
Pages:
1421-1431
Publication date:
2015-12-01
DOI:
EISSN:
1522-1601
ISSN:
8750-7587
Source identifiers:
527163
Language:
English
Keywords:
Pubs id:
pubs:527163
UUID:
uuid:05316df5-d28b-426a-bc51-ed59b6a0838a
Local pid:
pubs:527163
Deposit date:
2016-01-27

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