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TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites.

Abstract:

Understanding the modulation of the neural circuitry of fear is clearly one of the most important aims in neurobiology. Protein phosphorylation in response to external stimuli is considered a major mechanism underlying dynamic changes in neural circuitry. TrkB (Ntrk2) neurotrophin receptor tyrosine kinase potently modulates synaptic plasticity and activates signal transduction pathways mainly through two phosphorylation sites [Y515/Shc site; Y816/PLCgamma (phospholipase Cgamma) site]. To iden...

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Authors


Musumeci, G More by this author
Sciarretta, C More by this author
Rodríguez-Moreno, A More by this author
Al Banchaabouchi, M More by this author
Negrete-Díaz, V More by this author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
29
Issue:
32
Pages:
10131-10143
Publication date:
2009-08-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:052e07c8-fc73-4385-8fc0-f464daacef9d
Source identifiers:
329249
Local pid:
pubs:329249

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