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TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites.

Abstract:

Understanding the modulation of the neural circuitry of fear is clearly one of the most important aims in neurobiology. Protein phosphorylation in response to external stimuli is considered a major mechanism underlying dynamic changes in neural circuitry. TrkB (Ntrk2) neurotrophin receptor tyrosine kinase potently modulates synaptic plasticity and activates signal transduction pathways mainly through two phosphorylation sites [Y515/Shc site; Y816/PLCgamma (phospholipase Cgamma) site]. To iden...

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Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
29
Issue:
32
Pages:
10131-10143
Publication date:
2009-08-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Source identifiers:
329249

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