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Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis.

Abstract:

Despite the magnitude of the obesity epidemic, the mechanisms that contribute to increases in fat mass and to differences in fat depots are still poorly understood. Prostanoids have been proposed as potent adipogenic hormones, e.g. metabolites of prostaglandin J2 (PGJ2) bind and activate PPARgamma. We hypothesize that an altered expression of enzymes in PGJ2 synthesis may represent a novel pathogenic mechanism in human obesity. We characterized adipose depot-specific expression of enzymes in ...

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Publication status:
Published

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Publisher copy:
10.1016/j.gene.2006.05.026

Authors


Quinkler, M More by this author
Bujalska, IJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Stewart, PM More by this author
Journal:
Gene
Volume:
380
Issue:
2
Pages:
137-143
Publication date:
2006-10-05
DOI:
EISSN:
1879-0038
ISSN:
0378-1119
URN:
uuid:05232e66-35f2-4968-830f-e26ad3bd05e5
Source identifiers:
482101
Local pid:
pubs:482101

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