Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.

Journal article

BACKGROUND: Increased superoxide production contributes to reduced vascular nitric oxide (NO) bioactivity and endothelial dysfunction in experimental models of diabetes. We characterized the sources and mechanisms underlying vascular superoxide production in human blood vessels from diabetic patients with coronary artery disease compared with nondiabetic patients. METHODS AND RESULTS: Vascular superoxide production was quantified in both saphenous veins and internal mammary arteries from 45 ...

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Authors: Guzik, T; Mussa, S; Gastaldi, D; Sadowski, J; Ratnatunga, C

• Publication status: Published
• Journal: Circulation
• Volume: 105
• Issue: 14
• Pages: 1656-1662
• Publication date: 2002-04-01
• DOI: 10.1161/01.cir.0000012748.58444.08
• EISSN: 1524-4539
• ISSN: 0009-7322
• Language: English
• Keywords: Mammary Arteries; Saphenous Vein; Biopterin; Nitric Oxide Synthase; Humans; NADPH Dehydrogenase; Enzyme Inhibitors; Male; Female; Diabetes Mellitus; Protein Kinase C; Nitric Oxide Synthase Type III; Phosphoproteins; Signal Transduction; Membrane Transport Proteins; NADPH Oxidase; NADH, NADPH Oxidoreductases; Middle Aged; Superoxides; Blood Vessels; Endothelium, Vascular