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Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice.

Abstract:

The transcription factor Pax6 has been implicated in neocortical neurogenesis in vertebrates, including humans. Analyses of the role of Pax6 in layer formation and cognitive abilities have been hampered by perinatal lethality of Pax6 mutants. Here, we generated viable mutants exhibiting timed, restricted inactivation of Pax6 during early and late cortical neurogenesis using Emx1-Cre and hGFAP-Cre lines, respectively. The disruption of Pax6 at the onset of neurogenesis using Emx1-Cre line resu...

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Publication status:
Published

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Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience More from this journal
Volume:
29
Issue:
26
Pages:
8335-8349
Publication date:
2009-07-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474

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