Pin1 in neuronal apoptosis.

Journal article

While the role of the prolyl isomerase Pin1 in dividing cells has long been recognized, Pin1's function in postmitotic neurons is poorly understood. We have identified a novel mechanism by which Pin1 mediates activation of the mitochondrial cell death machinery specifically in neurons. This perspective presents a sophisticated signaling pathway that triggers neuronal apoptosis upon JNK-mediated phosphorylation of the BH3-only protein BIM(EL) at serine 65. Pin1 is enriched at the mitochondria ...

Expand abstract

Authors: Becker, E; Bonni, A

• Publication status: Published
• Journal: Cell cycle (Georgetown, Tex.)
• Volume: 6
• Issue: 11
• Pages: 1332-1335
• Publication date: 2007-06-01
• DOI: 10.4161/cc.6.11.4316
• EISSN: 1551-4005
• ISSN: 1538-4101
• Language: English
• Keywords: Membrane Proteins; Proto-Oncogene Proteins; JNK Mitogen-Activated Protein Kinases; Nervous System Diseases; Apoptosis; Apoptosis Regulatory Proteins; Cell Compartmentation; Signal Transduction; Mitochondria; Protein Conformation; Protein Structure, Tertiary; Phosphorylation; Neurons; Phosphoserine; Humans; Organ Specificity; Adaptor Proteins, Signal Transducing; Cell Cycle; Neoplasm Proteins; Animals; Cell Division; Rats; Mice; Protein Processing, Post-Translational