Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate.

Itoh, Y; Binner, S; Nagase, H

Abstract:

Tissue inhibitor of metalloproteinases (TIMP)-2 forms a noncovalent complex with the precursor of matrix metalloproteinase 2 (proMMP-2, progelatinase A) through interaction of the C-terminal domain of each molecule. We have isolated the proMMP-2-TIMP-2 complex from the medium of human uterine cervical fibroblasts and investigated the processes involved in its activation by 4-aminophenylmercuric acetate (APMA). The treatment of the complex with APMA-activated proMMP-2 by disrupting the Cys73-Z...

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APA Style

Itoh, Y., Binner, S., & Nagase, H. (1995). Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate. The Biochemical Journal, 308 ( Pt 2), 645–651.

MLA Style

Itoh, Y., et al. “Steps Involved in Activation of the Complex of pro-Matrix Metalloproteinase 2 (Progelatinase A) and Tissue Inhibitor of Metalloproteinases (TIMP)-2 by 4-Aminophenylmercuric Acetate.” The Biochemical Journal, vol. 308 ( Pt 2), The Biochemical journal, 1995, pp. 645–51.

Chicago Style

Itoh, Y, S Binner, and H Nagase. 1995. “Steps Involved in Activation of the Complex of pro-Matrix Metalloproteinase 2 (Progelatinase A) and Tissue Inhibitor of Metalloproteinases (TIMP)-2 by 4-Aminophenylmercuric Acetate.” The Biochemical Journal 308 ( Pt 2): 645–51.
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Authors

+ Itoh, Y More by this author

Institution:

University of Oxford

Department:

Oxford, MSD, NDORMS

Binner, S More by this author

Nagase, H More by this author

Bibliographic Details

Journal:: The Biochemical journal
Volume:: 308 ( Pt 2)
Pages:: 645-651
Publication date:: 1995-06-05
EISSN:: 1470-8728
ISSN:: 0264-6021
URN:: uuid:0511450c-487e-4c52-b585-4b934cc551d6
Source identifiers:: 411409
Local pid:: pubs:411409

Item Description

Language:: English
Keywords:: Tissue Inhibitor of Metalloproteinase-2

Enzyme Activation

Proteins

Cervix Uteri

Humans

Metalloendopeptidases

Enzyme Precursors

Macromolecular Substances

Phenylmercuric Acetate

Gelatinases

Matrix Metalloproteinase 2

Female

Protein Binding

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