Journal article
Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate.
- Abstract:
-
Tissue inhibitor of metalloproteinases (TIMP)-2 forms a noncovalent complex with the precursor of matrix metalloproteinase 2 (proMMP-2, progelatinase A) through interaction of the C-terminal domain of each molecule. We have isolated the proMMP-2-TIMP-2 complex from the medium of human uterine cervical fibroblasts and investigated the processes involved in its activation by 4-aminophenylmercuric acetate (APMA). The treatment of the complex with APMA-activated proMMP-2 by disrupting the Cys73-Z...
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Bibliographic Details
- Journal:
- The Biochemical journal
- Volume:
- 308 ( Pt 2)
- Pages:
- 645-651
- Publication date:
- 1995-06-05
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- URN:
-
uuid:0511450c-487e-4c52-b585-4b934cc551d6
- Source identifiers:
-
411409
- Local pid:
- pubs:411409
Item Description
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- Copyright date:
- 1995
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