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A novel noninvasive model of endometriosis for monitoring the efficacy of antiangiogenic therapy

Abstract:

Endometriosis, the presence of ectopic endometrial tissue, is a common disease associated with high morbidity and socioeconomic problems. Angiogenesis, the formation of new blood vessels, plays an important role in the formation and growth of endometriotic lesions. We have created a novel, noninvasive model to monitor the growth of these lesions and the associated angiogenesis in vivo. First, we generated luciferase-expressing transgenic mice by inserting the human ubiquitin C promoter couple...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2353/ajpath.2006.051133

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
Publisher:
Elsevier Inc. Publisher's website
Journal:
The American Journal of Pathology Journal website
Volume:
168
Issue:
6
Pages:
2074-2084
Publication date:
2006-06-05
Acceptance date:
2006-03-13
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:050e7e3b-6e3b-4295-8095-e3334c6cf282
Source identifiers:
485130
Local pid:
pubs:485130
Paper number:
6

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