Endogenous erythropoietin as part of the cytokine network in the pathogenesis of experimental autoimmune encephalomyelitis.

Journal article

Erythropoietin (EPO) is of great interest as a therapy for many of the central nervous system (CNS) diseases and its administration is protective in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Endogenous EPO is induced by hypoxic/ischemic injury, but little is known about its expression in other CNS diseases. We report here that EPO expression in the spinal cord is induced in mouse models of chronic or relapsing-remitting EAE, and is prominentl...

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Authors: Mengozzi, M; Cervellini, I; Bigini, P; Martone, S; Biondi, A

• Journal: Molecular medicine (Cambridge, Mass.)
• Volume: 14
• Issue: 11-12
• Pages: 682-688
• Publication date: 2008-01-01
• DOI: 10.2119/2008-00086.mengozzi
• EISSN: 1528-3658
• ISSN: 1076-1551
• Language: English
• Keywords: Animals; Reverse Transcriptase Polymerase Chain Reaction; Mice; Cell Line, Tumor; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Encephalomyelitis, Autoimmune, Experimental; Gene Expression; Cytokines; Immunohistochemistry; Interferon-gamma; Humans; Erythropoietin; Tumor Necrosis Factor-alpha; Spinal Cord