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Thesis

Synthetic studies towards sesquiterpenoids

Abstract:

Chapter 1 explores synthetic efforts carried out during this project towards α-bulnesene. Several radical cyclisation methods are discussed for constructing the 5,7-fused bicyclic framework. A concise and enantiospecific route to 5-epi-α-bulnesene, combining a new reductive rearrangement method, is presented.

Chapter 2 focuses on the total synthesis of daphnenoid A. A unique strategy towards this cage-like tetracyclic structure is developed via an intramolecular Diels–Alder reaction and a 20-step synthesis leading to an advanced intermediate to daphnenoid A is presented.

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
ORCID:
0000-0002-6809-8265

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
Keywords:
Subjects:
Deposit date:
2024-01-16

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