Journal article
Assaying the effect of levodopa on the evaluation of risk in healthy humans
- Abstract:
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In humans, dopamine is implicated in reward and risk-based decision-making. However, the specific effects of dopamine augmentation on risk evaluation are unclear. Here we sought to measure the effect of 100 mg oral levodopa, which enhances synaptic release of dopamine, on choice behaviour in healthy humans. We use a paradigm without feedback or learning, which solely isolates effects on risk evaluation. We present two studies (n = 20; n = 20) employing a randomised, placebo-controlled, within...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 458.8KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0068177
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PloS ONE More from this journal
- Volume:
- 8
- Issue:
- 7
- Pages:
- ARTN e68177
- Publication date:
- 2013-07-03
- Acceptance date:
- 2013-05-26
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- UUID:
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uuid:04f551e7-2a73-4383-b82c-d7979dc0a21d
- Local pid:
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pubs:411371
- Source identifiers:
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411371
- Deposit date:
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2013-11-16
Terms of use
- Copyright holder:
- Symmonds et al
- Copyright date:
- 2013
- Notes:
- Copyright: © 2013 Symmonds et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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