Macrophages and the hypoxic tumour microenvironment.

Journal article

Abstract:: One characteristic of solid tumour tissue is the presence of large numbers of tumour-associated macrophages. These migrate down gradients of chemo-attractive agents to accumulate within hypoxic and / or necrotic areas where they are generally related to poor clinical prognosis. In this review we will discuss the molecular mechanisms that underlie recruitment of macrophages into tumours and their pro-tumourigenic activities with respect to stimulation of angiogenesis, lymphangiogenesis, tumour cell migration, metastasis and immuno-suppression. The potential of macrophage-related anticancer therapies will be discussed in the light of this phenotype.

Journal:: Frontiers in bioscience : a journal and virtual library More from this journal
Volume:: 12
Issue:: 11
Pages:: 4298-4314
Publication date:: 2007-01-01
DOI:: 10.2741/2389
EISSN:: 1093-4715
ISSN:: 1093-9946

Language:: English
Keywords:: Cell Hypoxia

Humans

Prognosis

Neovascularization, Pathologic

Neoplasms

Antineoplastic Agents

Macrophages
Pubs id:: pubs:108460
UUID:: uuid:04f1473d-f1aa-4b47-b921-3e5d94f62041
Local pid:: pubs:108460
Source identifiers:: 108460
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_04f1473df1aa4b47b9213e5d94f62041

Licence:: Terms and Conditions of Use for Oxford University Research Archive

If you are the owner of this record, you can report an update to it here: Report update to this record