AChR phosphorylation and indirect inhibition of AChR function in seronegative MG.

Journal article

BACKGROUND: Approximately 10% to 20% of patients with autoimmune MG do not have antibodies to the acetylcholine receptor (AChR), so-called seronegative MG (SNMG). IgG antibodies from up to 70% of SNMG patients bind to the muscle-specific receptor tyrosine kinase, MuSK. The plasmas and non-IgG fractions from SNMG patients (and some with AChR antibodies) also contain a factor, perhaps an IgM antibody, that inhibits AChR function, but it is not clear how this factor acts and whether it is relate...

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Authors: Plested, C; Tang, T; Spreadbury, I; Littleton, E; Kishore, U

• Publication status: Published
• Journal: Neurology
• Volume: 59
• Issue: 11
• Pages: 1682-1688
• Publication date: 2002-12-01
• DOI: 10.1212/01.wnl.0000041625.41937.ff
• EISSN: 1526-632X
• ISSN: 0028-3878
• Language: English
• Keywords: Myasthenia Gravis; Adult; Receptor Protein-Tyrosine Kinases; Sodium; Electrophysiology; Receptors, Cholinergic; Autoantibodies; Child; Child, Preschool; Humans; Female; Adolescent; Protein Kinases; Infant; Cyclic AMP-Dependent Protein Kinases; Cholinergic Antagonists; Patch-Clamp Techniques; Immunoglobulin G; Cell Line; Male; Aged; Adenosine Triphosphate; Phosphorylation; Middle Aged