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Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function.

Abstract:

Lewy bodies are intracellular fibrillar inclusions composed of alpha-synuclein. They constitute the pathological hallmark of Parkinson's disease, dementia with Lewy bodies, and other neurodegenerative diseases. Although the majority of Lewy bodies are stained for ubiquitin by immunohistochemistry, the substrate for this modification is poorly understood. Insoluble, urea-soluble alpha-synuclein was separated from soluble fractions and subjected to two-dimensional gel electrophoresis to further...

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Publisher copy:
10.1074/jbc.m308041200

Authors


Journal:
The Journal of biological chemistry
Volume:
278
Issue:
45
Pages:
44405-44411
Publication date:
2003-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:04edfdb2-d0d6-49a0-9e64-360223113742
Source identifiers:
241203
Local pid:
pubs:241203

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